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Updated: Jun 26, 2026
07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Human basophils and cytokines/chemokines
Masao Yamaguchi1, Rikiya Koketsu, Maho Suzukawa
1Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. myama-tky@umin.net
Summary
Basophils, the least common white blood cells, are key players in allergic reactions. Cytokines and chemokines control their function, highlighting their proinflammatory role in type I allergies.
Area of Science:
- Immunology
- Allergy Pathogenesis
Background:
- Basophils are the least abundant leukocytes in human peripheral blood.
- Their precise role in allergic disease pathogenesis has been historically unclear.
- Tissue accumulation and activation suggest significant involvement.
Purpose of the Study:
- To elucidate the regulatory mechanisms of basophil function.
- To understand the specific roles of basophils in type I allergic reactions.
Main Methods:
- Review of recent advances in basophil biology.
- Analysis of the modulatory effects of cytokines and chemokines on basophils.
Main Results:
- Cytokines and chemokines are identified as primary regulators of basophil functions.
- Basophil functions are shown to be differentially modulated by various substances.
- Evidence indicates basophils act as unique effector cells.
Conclusions:
- Basophils, when exposed to allergens and regulatory substances, exhibit distinct proinflammatory roles.
- These cells are crucial effector cells in type I allergic reactions.
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