Related Experiment Video
Updated: Jun 26, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Nomograms for severity of aortic valve stenosis using peak aortic valve pressure gradient and left ventricular
Steffen P Schoen1, Till F Zimmermann, Charlotte Rosenberger
1Department of Cardiology and Intensive Care, Heart Center, University of Technology, Dresden, Fetscherstr. 76, 01307 Dresden, Germany. cardiology@email.de
Aims:
Continuity equation to evaluate aortic valve area (AVA(CE)) is critically dependent on accurate measurement of left ventricular outflow tract diameter and velocity. To circumvent these limitations, the present study aimed to generate nomograms for a facilitated estimation of aortic valve area using peak aortic valve pressure gradient (DeltapAv) and left ventricular ejection fraction (LVEF).
Methods And Results:
Two hundred and fifty-five subjects with non-invasively and invasively defined aortic valve stenosis (AS) formed the basis of this study. Basis of the nomograms was the correlation analysis between DeltapAv and AVA as estimated by AVA(CE) within different LVEF groups. LVEF differed from 65.6 +/- 1.8% (Group I, LVEF > 60%) to 34.5 +/- 4.3% (Group IV, LVEF > or = 30%). DeltapAv and AVA varied from 85.6 +/- 19.5 mmHg and 0.69 +/- 0.16 cm2 in Group I to 58.5 +/- 15.9 mmHg and 0.73 +/- 0.23 cm2 in Group IV (DeltapAv: P < 0.001). Mean AVA(CE) showed no significant difference between the groups. Correlation between DeltapAv and AVA(CE) was statistically significant with P < 0.001 in all subgroups (R2 between 0.72 and 0.76). Furthermore, a prospective estimation of AVA using the developed nomograms correlated very well with invasively determined AS using the Gorlin formula (R2 = 0.76, SEE = 0.21 cm2, bias 0.04 cm2).
Conclusion:
The present study has established and confirmed a solid, easy to use nomogram-based method to accurately quantify severe AS.
Related Concept Videos
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis I: Introduction
Aortic Regurgitation I: Introduction
Mitral Stenosis IV: Nursing Management
Aortic Regurgitation III: Medical Management