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Related Experiment Video

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Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems

Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems

Published on: October 14, 2025

Predicting protein evolution in vitro by phage escape technology.

Amanda S Rohrbach¹, Tobin J Dickerson

¹Department of Chemistry and Worm Institute for Research and Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

Molecular Biosystems

|January 22, 2009

Summary

This summary is machine-generated.

Predicting pathogen evolution is key to controlling diseases. A new bacteriophage technology screens millions of binding events, mimicking protein evolution to anticipate resistance and improve treatments.

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In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity

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Published on: March 25, 2020

Area of Science:

Evolutionary biology
Immunology
Molecular biology

Background:

Host-pathogen interactions are genetically dynamic, driving pathogen evolution.
Host defenses pressure pathogens to develop resistance and immune evasion mechanisms.
Predicting pathogen evolution is crucial for effective disease control.

Purpose of the Study:

To introduce a novel bacteriophage-based technology for screening protein evolution.
To demonstrate its utility in modeling host-pathogen coevolution.
To provide a predictive tool for developing effective disease control strategies.

Main Methods:

Utilized bacteriophage display technology to screen millions of binding events.
Applied single-molecule resolution to mimic in vitro protein evolution.
Modeled protein evolution under selective pressures like antibodies.

Main Results:

The phage escape technology enables high-throughput screening of protein-antibody interactions.
It successfully models the evolutionary dynamics between hosts and pathogens.
Provides insights into the emergence of resistance and immune evasion.

Conclusions:

Phage escape technology offers a predictive solution for antigen-immune system coevolution.
This approach can enhance vaccine development and disease treatment strategies.
It has significant implications for managing rapidly evolving diseases like viral infections and cancer.