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Insights into Lichen Planus Pigmentosus Inversus using Minimally Invasive Dermal Patch and Whole Transcriptome

Jacob Dickman1, Michael Howell1, Robert Hoopes1

  • 1Department of Pharmacology & Toxicology, Wright State University, Dayton Ohio.

Journal of Clinical and Investigative Dermatology
|August 25, 2022
PubMed
Summary
This summary is machine-generated.

Lichen Planus Pigmentosus inversus (LPPi) involves interferon signaling and T-cell activation, distinct from Lichen Planus (LP). This study used a dermal biomarker patch for minimally invasive analysis, revealing unique gene expression profiles in LPPi.

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Area of Science:

  • Dermatology
  • Immunology
  • Molecular Biology

Background:

  • Lichen Planus Pigmentosus inversus (LPPi) is a rare variant of lichen planus (LP) presenting as pigmented macules in skin folds.
  • Clinical differentiation between LPPi and LP can be challenging, necessitating invasive biopsies for diagnosis.
  • Limited molecular studies exist to elucidate the distinct pathogenesis of LPPi.

Purpose of the Study:

  • To investigate the molecular differences between LPPi and LP using minimally invasive techniques.
  • To identify specific biomarkers and pathways involved in LPPi pathogenesis.
  • To explore the utility of dermal biomarker patches in diagnosing interface and lichenoid dermatitis (ILD).

Main Methods:

  • Whole transcriptome analysis was performed on samples from 3 patients (2 LPPi, 1 LP) using a dermal biomarker patch.
  • Minimally invasive sampling technique was employed.
  • Gene expression profiling was compared between LPPi and LP patients.

Main Results:

  • Interferon signaling and T-cell activation were confirmed in LPPi.
  • LPPi demonstrated a distinct gene expression profile compared to LP.
  • Upregulated genes in LPPi included a splice variant of the primary pigmentation determining receptor and genes involved in ceramide synthesis and cornified envelope construction.

Conclusions:

  • This study expands the understanding of LPPi pathogenesis, highlighting molecular distinctions from LP.
  • The findings support the role of interferon signaling and T-cell activation in LPPi.
  • Minimally invasive dermal biomarker patch technology shows potential for clinical diagnostics in ILDs.