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Novel Histopathologic Features of Diffuse Blue-Gray Hyperpigmentation Associated With Kratom Use: A Case Report and

Rita Kamoua1, Kristen Paradine1, Craig A Rohan1,2

  • 1Wright State University Boonshoft School of Medicine, Fairborn, Ohio, USA.

Journal of Cutaneous Pathology
|January 8, 2026
PubMed
Summary

Kratom (Mitragyna speciosa) use can cause drug-induced hyperpigmentation, a skin condition often misdiagnosed. This case highlights unique histopathological findings and the importance of considering herbal supplements in patient history.

Keywords:
blue‐gray pigmentationdermatopathologydrug‐induced hyperpigmentationkratomskin pigmentation disorders

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