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Published on: March 6, 2018
Alcohol use and prostate cancer: a meta-analysis
Kaye Middleton Fillmore1, Tanya Chikritzhs, Tim Stockwell
1National Drug Research Institute, Curtin University, Perth, Australia.
Molecular Nutrition & Food Research
|January 22, 2009
Summary
Heavy alcohol use may increase prostate cancer risk, contrary to previous reviews. Population case-control studies, especially those with younger participants, showed this link, suggesting better temporal measurement of alcohol consumption. Future research should refine control groups.
Area of Science:
- Epidemiology
- Oncology
- Public Health
Background:
- Previous reviews found no link between alcohol consumption and prostate cancer.
- This study re-evaluates the alcohol-prostate cancer association using a meta-analysis.
Purpose of the Study:
- To investigate the association between alcohol use and prostate cancer incidence.
- To identify potential biases in previous epidemiological studies.
Main Methods:
- Meta-analysis of existing epidemiological studies on alcohol consumption and prostate cancer.
- Analysis of study design effects, including population case-control, cohort, and hospital case-control studies.
- Examination of participant age at recruitment and control group composition.
Main Results:
- A positive linear association was found between heavier alcohol use and prostate cancer incidence.
- This association was primarily driven by population case-control studies and studies with men recruited before age 60.
- No significant association was observed in cohort and hospital case-control studies.
Conclusions:
- Heavier alcohol consumption may be associated with increased prostate cancer risk.
- Population case-control studies may be better suited to detect this association due to temporal proximity of exposure measurement.
- Methodological improvements, such as excluding ill subjects from control groups and accounting for age-related consumption changes, are recommended for future research.
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