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A Protocol to Infect Caenorhabditis elegans with Salmonella typhimurium
Published on: June 26, 2014
Salmonella takes control: effector-driven manipulation of the host
Emma J McGhie1, Lyndsey C Brawn, Peter J Hume
1University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK. ejm37@cam.ac.uk
Current Opinion in Microbiology
|January 23, 2009
Summary
Salmonella uses specialized proteins delivered by secretion systems to control host cells, enabling invasion and replication. This review details how these Salmonella effectors target host cells during infection.
Area of Science:
- Microbiology
- Cell Biology
- Infectious Diseases
Background:
- Salmonella pathogenesis involves effector proteins delivered into host cells.
- Two distinct type III secretion systems facilitate effector protein delivery.
Purpose of the Study:
- To review the actions of Salmonella effector proteins on host cell targets.
- To elucidate the mechanisms of Salmonella infection stages.
Main Methods:
- Literature review of Salmonella effector protein functions.
- Analysis of host-pathogen interactions during infection.
Main Results:
- Salmonella effectors subvert host cytoskeleton, signaling, and membrane trafficking.
- Effectors modulate host pro-inflammatory responses.
- These actions facilitate host cell invasion and intracellular replication.
Conclusions:
- Salmonella effector proteins are crucial for establishing infection.
- Understanding these effectors aids in developing therapeutic strategies.
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