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Related Concept Videos

Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
Ribosomes01:27

Ribosomes

Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome production. Within...

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Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
07:55

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Published on: May 31, 2011

Finding 3D motifs in ribosomal RNA structures.

Alberto Apostolico1, Giovanni Ciriello, Concettina Guerra

  • 1College of Computing, Georgia Institute of Technology, Atlanta, GA 30332-0280, USA.

Nucleic Acids Research
|January 23, 2009
PubMed
Summary

This study introduces a new geometric method to identify structural motifs in 3D RNA molecules. The approach effectively recognizes known motifs and characterizes complex 3D structures like junctions in ribosomal RNA.

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Area of Science:

  • Structural Biology
  • Computational Biology
  • Bioinformatics

Background:

  • Understanding RNA 3D structures is crucial for predicting and designing RNA molecules.
  • Existing methods primarily focus on RNA secondary structures, with limited analysis of 3D motifs.

Purpose of the Study:

  • To develop a novel geometric method for characterizing and identifying structural motifs in 3D RNA.
  • To enable efficient recognition of known 3D RNA motifs and classification of complex 3D structures.

Main Methods:

  • A novel geometric approach was developed for 3D RNA motif identification.
  • The method was applied to analyze structural motifs in the Haloarcula marismortui large ribosomal unit.

Main Results:

  • The method successfully identified known 3D motifs like tetraloops and kink-turns.
  • It provided a new way to characterize complex 3D motifs, such as junctions, in ribosomal RNA.

Conclusions:

  • The developed geometric method is effective for identifying and characterizing 3D RNA structural motifs.
  • This approach advances the analysis and design of complex RNA structures, particularly in ribosomal RNA.