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Standardized Measurement of Nasal Membrane Transepithelial Potential Difference (NPD)
Published on: September 13, 2018
Non-invasive ventilation for cystic fibrosis
Fidelma Moran1, Judy M Bradley, Amanda J Piper
1Room 14J07, School of Health Sciences, University of Ulster, Shore Road, Newtownabbey, Northern Ireland, UK, BT37 0QB. f.moran@ulster.ac.uk
Non-invasive ventilation (NIV) may aid airway clearance and improve lung function in cystic fibrosis (CF) patients. While NIV shows promise for airway clearance and exercise performance, its long-term effects on CF progression require further study.
Area of Science:
- Pulmonary Medicine
- Respiratory Care
- Clinical Trials
Background:
- Cystic Fibrosis (CF) is a genetic disorder affecting the lungs, leading to respiratory failure.
- Non-invasive ventilation (NIV) is explored as a potential intervention to manage respiratory issues in CF patients.
Purpose of the Study:
- To evaluate the efficacy of non-invasive ventilation (NIV) compared to no NIV in individuals with cystic fibrosis (CF).
Main Methods:
- Systematic review of randomized controlled trials (RCTs) identified through comprehensive database searches and trial registers.
- Included trials compared pressure-preset or volume-preset NIV with no NIV in CF patients experiencing acute or chronic respiratory failure.
- Data extraction and quality assessment were performed independently by three reviewers.
Main Results:
- Seven trials involving 106 participants were analyzed.
- NIV may facilitate airway clearance and improve lung function parameters in CF patients.
- Overnight NIV showed potential benefits in exercise performance compared to room air over six weeks, but results were limited by small sample sizes.
Conclusions:
- Non-invasive ventilation (NIV) may serve as a beneficial adjunct to airway clearance techniques for individuals with cystic fibrosis (CF), especially those with sputum expectoration difficulties.
- NIV, when used with oxygen, might enhance gas exchange during sleep in moderate to severe CF.
- Further long-term, adequately powered RCTs are necessary to ascertain the clinical impact of NIV on CF airway clearance, exercise, and disease progression.
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