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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jun 26, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Very early versus delayed mobilisation after stroke.

Julie Bernhardt1, Matthew Nt Thuy, Janice M Collier

  • 1Very Early Rehabilitation Stroke Research Program, National Stroke Research Institute, Level 1, Neurosciences Building, Austin Health, Repatriation Campus, 300 Waterdale Road, Heidelberg Heights, Victoria, Australia, 3081. j.bernhardt@unimelb.edu.au

The Cochrane Database of Systematic Reviews
|January 23, 2009
PubMed
Summary
This summary is machine-generated.

Very early mobilisation after stroke shows no significant benefit over conventional care. More research is needed to determine the efficacy and safety of early mobilisation strategies for stroke patients.

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

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Last Updated: Jun 26, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

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Published on: February 22, 2020

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Very early mobilisation is recommended in acute stroke guidelines but its independent benefit is unclear.
  • Current evidence on the efficacy of early mobilisation post-stroke is limited.

Purpose of the Study:

  • To evaluate the benefits and harms of very early mobilisation (within 48 hours) compared to conventional care in acute stroke patients.

Main Methods:

  • Systematic review of randomised controlled trials (RCTs) comparing early mobilisation with conventional care.
  • Searched multiple databases including Cochrane, MEDLINE, EMBASE, CINAHL, AMED, and Wanfangdata.
  • Primary outcome: death or poor outcome (dependency/institutionalisation); Secondary outcomes: mortality, ADLs, quality of life, adverse events.

Main Results:

  • One RCT with 71 participants was included.
  • Early mobilisation group had more frequent mobilisation (167 min vs 69 min).
  • No statistically significant difference in death or disability at 3 months (OR 0.67, 95% CI 0.25-1.79).

Conclusions:

  • Insufficient evidence to support or refute the routine use of very early mobilisation after stroke.
  • Further research is required to establish the benefits and harms of early mobilisation interventions.