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Related Experiment Video

Updated: Jun 26, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
10:00

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Published on: March 24, 2015

Interferon beta for primary progressive multiple sclerosis.

Juan Ignacio Rojas1, Marina Romano, Agustín Ciapponi

  • 1Neurology Department, Hospital Italiano Buenos Aires, Gascon 450, Buenos Aires, Buenos Aires, Argentina, 1411. juan.rojas@hospitalitaliano.org.ar

The Cochrane Database of Systematic Reviews
|January 23, 2009
PubMed
Summary
This summary is machine-generated.

Interferon beta (ss-interferon) did not reduce disability progression in primary progressive multiple sclerosis (PPMS) patients. More research is needed due to limited data and small trial sizes for this multiple sclerosis subtype.

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Last Updated: Jun 26, 2026

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Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
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Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

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Area of Science:

  • Neurology
  • Immunology

Background:

  • Multiple Sclerosis (MS) treatment trials predominantly focus on relapsing-remitting MS (RRMS).
  • Limited evidence exists regarding the efficacy of interferon beta (ss-interferon) in primary progressive multiple sclerosis (PPMS).

Purpose of the Study:

  • To identify and summarize evidence on the benefits and safety of ss-interferon for PPMS patients.
  • Evaluate the impact of ss-interferon on disease progression and adverse events in PPMS.

Main Methods:

  • Comprehensive literature search of multiple databases (Cochrane, MEDLINE, EMBASE, etc.) until April 2008.
  • Included randomized, double or single-blind, placebo-controlled trials of ss-interferon in PPMS.
  • Two independent reviewers assessed trial quality and extracted data.

Main Results:

  • Two randomized controlled trials (123 patients) met the inclusion criteria.
  • ss-interferon did not demonstrate a significant difference in disease progression compared to placebo (RR 0.89, 95% CI 0.55 to 1.43).
  • Increased adverse events were observed with ss-interferon (RR 1.90, 95% CI 1.45-2.48), but MRI showed reduced active lesions.

Conclusions:

  • Current limited data suggests ss-interferon does not reduce disability progression in PPMS.
  • The small sample size precludes definitive conclusions on ss-interferon efficacy in PPMS.
  • Larger studies are necessary to clarify the role of ss-interferon therapy in PPMS.