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Related Experiment Video

Updated: Jun 26, 2026

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

T(2) relaxometry of normal pediatric brain development.

Ilana R Leppert1, C Robert Almli, Robert C McKinstry

  • 1Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. ilana@bic.mni.mcgill.ca

Journal of Magnetic Resonance Imaging : JMRI
|January 24, 2009
PubMed
Summary

This study maps age-related changes in brain T(2) relaxation times in children up to 4.5 years old. The findings reveal a consistent pattern of T(2) evolution reflecting normal brain development.

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Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Biophysics

Background:

  • Brain development involves significant changes in water content and myelination.
  • Magnetic Resonance (MR) T(2) relaxation time constants are sensitive to these tissue microstructural changes.
  • Establishing normative data is crucial for understanding typical development and identifying abnormalities.

Purpose of the Study:

  • To characterize normal age-related changes in brain T(2) relaxation time constants.
  • To utilize data from the National Institutes of Health (NIH) MRI Study of Normal Brain Development.
  • To provide a normative reference for pediatric brain development.

Main Methods:

  • Analysis of over 340 MRI scans from healthy children (birth to 4 years 5 months).

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Scanning Dos and Don'ts: Using Magnetic Resonance Imaging in Awake Children Aged 3 to 5 Years to Assess Brain Structure and Function
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Scanning Dos and Don'ts: Using Magnetic Resonance Imaging in Awake Children Aged 3 to 5 Years to Assess Brain Structure and Function

Published on: March 10, 2026

Related Experiment Videos

Last Updated: Jun 26, 2026

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

Scanning Dos and Don'ts: Using Magnetic Resonance Imaging in Awake Children Aged 3 to 5 Years to Assess Brain Structure and Function
07:31

Scanning Dos and Don'ts: Using Magnetic Resonance Imaging in Awake Children Aged 3 to 5 Years to Assess Brain Structure and Function

Published on: March 10, 2026

  • Multicenter study employing both longitudinal and cross-sectional data collection.
  • Use of inanimate and human phantoms to ensure data quality and assess variability.

    • Main Results:

    • Identification and parameterization of monoexponential T(2) evolution across various brain structures.
    • Demonstration of a consistent T(2) decay pattern from birth through 4 years 5 months.
    • Quantification of age-related T(2) changes in pediatric brain development.

    Conclusions:

    • The observed T(2) decay reflects dynamic changes in brain water content and myelination.
    • The generated normative data will serve as a valuable resource for research.
    • This database will aid in the assessment of normal brain development and the study of developmental disorders.