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Cerebral extension of steroid-responsive meningitis arteritis in a boxer

M Wrzosek1, M Konar, M Vandevelde

  • 1Division of Clinical Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

The Journal of Small Animal Practice
|January 24, 2009
PubMed

Insights

Steroid-responsive meningitis arteritis can affect a dog's entire brain and spinal cord, presenting as a severe neurological condition. This case highlights its extensive presentation, crucial for diagnosing suspected intracranial infections.

Area of Science:

  • Veterinary Neurology
  • Immunology

Background:

  • Steroid-responsive meningitis arteritis (SRMA) is an immune-mediated inflammatory disease affecting dogs.
  • Typically, SRMA involves inflammation of the meninges, particularly around the base of the brain.

Observation:

  • A 30-month-old boxer presented with seizures and neurological deficits.
  • Advanced imaging revealed widespread cerebral grey matter and ependymal lining changes with ventricular sediment.
  • Cerebrospinal fluid analysis showed elevated protein and polymorphonuclear pleocytosis.

Findings:

  • Pathological examination confirmed fibrinosuppurative meningo-ependymitis and necrotizing arteritis throughout the brain.
  • Chronic inflammation and arterial stenosis were noted in the spinal meninges.
  • No infectious agents were identified, leading to a diagnosis of SRMA.

Implications:

  • This case demonstrates an unusually extensive SRMA affecting the forebrain's meninges and ventricular system.
  • The findings expand the differential diagnosis for suspected intracranial suppurative infections in dogs.
  • Recognizing this severe presentation is vital for accurate diagnosis and management of SRMA.

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