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Updated: Jun 26, 2026

A Polyaniline-based Sensor of Nucleic Acids
07:58

A Polyaniline-based Sensor of Nucleic Acids

Published on: November 1, 2016

STD sensor based on nucleic acid functionalized nanostructured polyaniline.

Renu Singh1, Rachna Prasad, G Sumana

  • 1Biomolecular Electronics and Conducting Polymer Research Group, National Physical Laboratory, Dr. K.S. Krishnan Marg, New Delhi 110012, India.

Biosensors & Bioelectronics
|January 24, 2009
PubMed
Summary
This summary is machine-generated.

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A novel sensor detects gonorrhea (sexually transmitted disease) using a DNA-functionalized electrode. This highly sensitive gonorrhea sensor achieves rapid and specific detection in patient samples.

Area of Science:

  • Electrochemistry
  • Biosensors
  • Molecular Diagnostics

Background:

  • Sexually transmitted diseases (STDs) like gonorrhea require rapid and accurate diagnostic tools.
  • Current diagnostic methods may lack the sensitivity or speed needed for effective public health interventions.

Purpose of the Study:

  • To develop a highly sensitive and specific electrochemical sensor for the detection of Neisseria gonorrhoeae.
  • To utilize a nanostructured polyaniline platform functionalized with nucleic acid probes for enhanced detection capabilities.

Main Methods:

  • Fabrication of a DNA-functionalized electrode using nanostructured polyaniline on an indium-tin-oxide coated glass plate.
  • Employing avidin-biotin for cross-linking nucleic acid probes targeting a multi-copy gene (Opa) of Neisseria gonorrhoeae.

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Last Updated: Jun 26, 2026

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  • Utilizing differential pulse voltammetry (DPV) with methylene blue as a hybridization indicator for detection.

    • Main Results:

    • The sensor demonstrated high specificity, detecting complementary targets down to 0.5 x 10(-15)M.
    • Rapid detection was achieved within 60 seconds of hybridization at 25 degrees C.
    • The sensor successfully distinguished Neisseria gonorrhoeae from Neisseria meningitidis and Escherichia coli in culture and patient samples.

    Conclusions:

    • A novel, highly sensitive, and specific electrochemical sensor for gonorrhea detection has been successfully developed.
    • The nanostructured polyaniline-based nucleic acid sensor offers a promising platform for rapid STD diagnostics.
    • This technology has the potential to improve the diagnosis of gonorrhea in clinical settings.