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Generation of a Human iPSC-Based Blood-Brain Barrier Chip
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Building a brain on a chip.

Bruce C Wheeler1

  • 1University of Florida, Crayton Pruitt Family Department of Biomedical Engineering, Gainesville, USA. bwheeler@ufl.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 24, 2009
PubMed
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Engineered nerve cells in culture are moving closer to reliable computation, integrating engineering and biology. This research explores novel methods for neural cell growth, recording, and stimulation, paving the way for biological computing.

Area of Science:

  • Neuroscience
  • Bioengineering
  • Computational Biology

Background:

  • Investigates the feasibility of nerve cells in culture performing reliable computational functions.
  • Highlights the synergy between engineering disciplines and applied biology in advancing neural engineering.

Discussion:

  • Details how traditional engineering technologies like signal processing, electronics, and materials science enable controlled neural cell growth, recording, and stimulation.
  • Explores how an engineering approach to biological constructs prompts novel research questions.

Key Insights:

  • Demonstrates the practical application of engineering principles in creating functional biological computing systems.
  • Showcases component technologies and methodologies developed for neural engineering.

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Last Updated: Jun 26, 2026

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Outlook:

  • Addresses the challenges in analyzing complex, high-dimensional, and non-stationary neural spike data.
  • Presents a forward-looking perspective on the potential of engineered neural constructs for computation.