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Related Experiment Video

Updated: Jun 26, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

Vascular endothelial growth factor.

Napoleone Ferrara¹

¹Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA. nf@gene.com

Arteriosclerosis, Thrombosis, and Vascular Biology

|January 24, 2009

Summary

This summary is machine-generated.

Vascular Endothelial Growth Factor (VEGF) discovery faced challenges, but its crucial role in blood vessel formation (angiogenesis) was uncovered. This review details early research into VEGF

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Last Updated: Jun 26, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

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Area of Science:

Molecular Biology
Cell Biology
Biochemistry

Background:

Vascular Endothelial Growth Factor (VEGF) is a key regulator of angiogenesis.
Dysregulation of VEGF is implicated in diseases like cancer and macular degeneration.
VEGF inhibitors are FDA-approved for treating advanced cancers and neovascular age-related macular degeneration.

Observation:

The discovery of VEGF involved overcoming significant scientific hurdles.
Early research focused on understanding VEGF's fundamental role in blood vessel development.
Elucidating VEGF's function was critical for therapeutic advancements.

Findings:

VEGF's pivotal role in both normal and abnormal angiogenesis is well-established.
The identification of VEGF paved the way for targeted therapies.
Understanding VEGF's regulatory mechanisms is essential for disease treatment.

Implications:

The discovery of VEGF has revolutionized the treatment of angiogenesis-driven diseases.
Further research into VEGF pathways may yield novel therapeutic strategies.
Targeting VEGF remains a cornerstone in oncology and ophthalmology.