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Updated: Jun 26, 2026
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
Published on: September 13, 2018
Hippo signaling pathway and organ size control
Lei Zhang1, Tao Yue, Jin Jiang
1Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Fly
|January 24, 2009
Summary
The Hippo (Hpo) pathway, crucial for organ size control, restricts cell growth and proliferation. Its dysregulation is linked to human cancers, highlighting its role in development and tumorigenesis.
Area of Science:
- Developmental Biology
- Cell Signaling
- Cancer Biology
Background:
- The Hippo (Hpo) pathway is a conserved signaling network regulating organ size.
- It controls cell proliferation, apoptosis, and growth.
- Aberrant Hpo pathway activity is implicated in human cancers.
Purpose of the Study:
- To review the molecular and cellular mechanisms of Hpo signaling.
- To discuss the role of Hpo in development and tumorigenesis.
- To explore how Hpo integrates signals for tissue growth control.
Main Methods:
- Literature review of Hpo pathway research.
- Analysis of molecular and cellular data.
- Synthesis of findings on Hpo signaling.
Main Results:
- The Hpo pathway acts as a critical regulator of organ size.
- It balances cell growth, proliferation, and apoptosis.
- Hpo pathway components are frequently altered in various cancers.
Conclusions:
- The Hpo pathway is essential for maintaining tissue homeostasis.
- Understanding Hpo signaling provides insights into developmental processes.
- Targeting the Hpo pathway may offer therapeutic strategies for cancer.
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