Laser-based in situ techniques: novel methods for generating extreme conditions in TEM samples
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Updated: Jun 26, 2026

Laser-Induced Fluorescence Emission (L.I.F.E.) as Novel Non-Invasive Tool for In-Situ Measurements of Biomarkers in Cryospheric Habitats
Published on: October 26, 2019
Mitra L Taheri1, Thomas Lagrange, Bryan W Reed
1Chemistry, Materials, Earth & Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA. mtaheri@coe.drexel.edu
Abstract:
The dynamic transmission electron microscope (DTEM) is introduced as a novel tool for in situ processing of materials. Examples of various types of dynamic studies outline the advantages and differences of laser-based heating in the DTEM in comparison to conventional (resistive) heating in situ TEM methods. We demonstrate various unique capabilities of the drive laser, namely, in situ processing of nanoscale materials, rapid and high temperature phase transformations, and controlled thermal activation of materials. These experiments would otherwise be impossible without the use of the DTEM drive laser. Thus, the potential of the DTEM as a new technique to process and characterize the growth of a myriad of micro and nanostructures is demonstrated.
