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Updated: Jun 26, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
[Formulation optimization of controlled porosity osmotic-pump tablets of total paeony glycosides]
1Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518029, China. ycahui@163.com
Objective:
To prepare controlled porosity osmotic-pump tablets of total paeony glycosides (TPG) and establish the relationship between formulation factors of membrane and drug release rate.
Method:
Uniform design was used to achieve the quantitative relationship between the release rate and formulation factors of membrane. Optimized prescription was calculated from the regression equation.
Result:
A significant correlation and a fine precision of the regession equation were obtained. Controlled porosity osmotic-pump tablets of TPG were prepared based on the calculations, and the drug release profile was in accord with zero-order kinetics (r = 0.9902).
Conclusion:
Uniform design is a convenient and efficient approach for formulation optimization of controlled porosity osmotic-pump tablets.
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