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[Helicobacter pylori infection in childhood revealed by hematemesis: endoscopic and pathologic patterns]
Sonia Mazigh Mrad1, Samir Boukthir, Lamia Gharsallah
1Service de Médecine Infantile C - Hôpital d'Enfants de Tunis.
Insights
Helicobacter pylori (Hp) infection is common in children with upper gastrointestinal bleeding, often linked to chronic gastritis. Investigating and eradicating Hp is crucial for severe symptoms like hematemesis.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Gastrointestinal Endoscopy
Background:
- The prevalence of Helicobacter pylori (Hp) infection in pediatric hematemesis cases is not well-documented.
- Upper gastrointestinal bleeding in children necessitates understanding underlying causes, including infectious agents.
Purpose of the Study:
- To determine the frequency of Hp infection in children experiencing upper gastrointestinal bleeding.
- To analyze the endoscopic and histological characteristics associated with Hp infection in this pediatric cohort.
Main Methods:
- A retrospective study of 180 children with upper gastrointestinal bleeding who underwent endoscopy.
- Two groups were analyzed: those who had gastric biopsies (n=95) and those who did not (n=95).
- Data collected included patient history, bleeding severity, medication use, and endoscopic/histological findings.
Main Results:
- Helicobacter pylori infection was identified in 48% of the children studied.
- A significant association was found between Hp infection and chronic gastritis (p>10^-6).
- No significant differences were observed between infected and non-infected groups regarding age, bleeding severity, or other clinical parameters.
Conclusions:
- Helicobacter pylori infection is highly prevalent in children with upper gastrointestinal bleeding and hematemesis.
- Incomplete diagnostic investigations may lead to underestimation of Hp infection rates.
- Systematic investigation and eradication of Hp infection are recommended for pediatric patients presenting with severe gastrointestinal symptoms indicative of organic disease.
Background:
Helicobacter pylori infection frequency in hematemesis was scarcely studied.
Aim:
to asses the frequency of this infection in children with upper gastrointestinal bleeding and to study the endoscopic and histological features.
Methods:
It is a retrospective study including 180 children who underwent an endoscopy for upper gastrointestinal bleeding. Our population was divided in two groups. The group 1 (n=95) has performed gastric biopsy. The group 2 (n=95) has'nt performed gastric biopsy. For each group, we studied the personal and familial history of gastroenterologic disease, the hospital where they come from, the importance of bleeding, the drug intake effecting the gastric mucosa, the endoscopic and histological features.
Results:
The helicobacter pylori infection was present in 48% of the children. The mean age of these children was 99.8 +/- 42.1 months versus 95.7 +/- 44 months (p=0.13) The comparison of the two groups according to Hp infection, and the others parameters don't found any differences. All the infected children have chronic gastritis 40/40 versus 13/44 in the non infected children (p>10 -6).
Conclusion:
The frequency of Hp infection was high in this group of patients with upper gastrointestinal bleeding. It was probably underestimated because the investigation was not complete. We emphasize that Hp infection has to be investigated and systematically eradicated whenever there were severe symptoms like hematemesis indicating therefore organic disease.
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