Related Experiment Video
Updated: Jun 26, 2026

Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1
Published on: May 27, 2016
Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial
Dong Wook Kim1, Sang Kun Lee, Kon Chu
1Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea.
Abstract:
ATP-binding cassette (ABC) transporters participate in drug disposition and response in various conditions, and many polymorphisms in ABC transporter genes have been recognized in association with altered transporter functions of various drugs. Studies on epilepsy have focused on the C3435T polymorphism of the ABCB1 gene, but other ABC transporters are also thought to be involved in the transport of antiepileptic drugs. We have evaluated the functional polymorphisms of ABCB1, ABCG2, and ABCC2 genes with regard to epilepsy drug response in partial epilepsy, and have investigated the potential of combined effects of polymorphisms in more than one transporter gene. We studied 6 genetic polymorphisms in 3 transporter genes in 193 drug responders and 198 nonresponders. There was no significant difference between the two groups, and we did not observe any combined effects of ABCB1 and ABCG2 genetic polymorphisms. Our study suggests that genetic polymorphisms in ABC transporters may not be significant predictors of drug response in epilepsy patients.
Related Concept Videos
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters
ABC Transporters: Exporter
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
ABC Transporters: Importer
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
Pharmacogenetics of Drug Metabolism: Overview
