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Updated: Jun 26, 2026

Synthesis of Indoxyl-glycosides for Detection of Glycosidase Activities
Published on: May 27, 2015
Stereoselective synthesis of bioactive isosteviol derivatives as alpha-glucosidase inhibitors
Ya Wu1, Jing-Hua Yang, Gui-Fu Dai
1Department of Chemistry, New Drug Research & Development Center, Zhengzhou University, Zhengzhou, China.
Abstract:
Considerable interest has been attracted in isosteviol and its derivatives because of their large variety of pharmacological activities. In this project, a series of novel compounds containing hydroxyl, hydroxymethyl group and heteroatom-containing frameworks fused with isosteviol structure were synthesized and evaluated as alpha-glucosidase inhibitors, aimed at clarifying the structure-activity correlation. The results indicated that these isosteviol derivatives were capable of inhibiting in vitro alpha-glucosidase with moderate to good activities. Among them, indole derivative 15b exhibited the highest activities and thus may be exploitable as a lead compound for the development of potent alpha-glucosidase inhibitors.
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