Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision oncology without borders: the role of biobanking in integrating Africa's genetic diversity into global genomic research.

NPJ precision oncology·2026
Same author

Immunohistochemical Analysis of pH-Sensitive TRPV5 in Common Skin Tumors.

International journal of molecular sciences·2026
Same author

Structured micro-ultrasonography training improves prostate cancer detection and management decisions.

BJU international·2026
Same author

Intraperitoneal G-CSF Stimulation Achieves Human-like Neutrophil Levels in NSG Mice Without Inducing Systemic Inflammation.

International journal of molecular sciences·2026
Same author

Tissue biobanking: minimum interface requirements for efficient and high-quality support for biomedical research - a white paper.

Virchows Archiv : an international journal of pathology·2026
Same author

Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis.

Cell communication and signaling : CCS·2026

Related Experiment Video

Updated: Jun 26, 2026

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Adhesion prophylaxis using a copolymer with rationally designed material properties.

Taufiek Konrad Rajab1, Christian Wilhelm Wallwiener, Christoph Brochhausen

  • 1University of Tübingen, Tübingen, Germany; Imperial College London, London, UK. taufiek.rajab@imperial.ac.uk

Surgery
|January 27, 2009
PubMed
Summary
This summary is machine-generated.

D,L-polylactide-epsilon-caprolactonetrimethylenecarbonate (PCT) copolymer membranes effectively reduced post-surgical adhesions in a rat model. This biocompatible material proved suitable for human laparoscopic use, warranting further clinical trials.

More Related Videos

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
06:15

Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion

Published on: August 15, 2016

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Surgical innovation

Background:

  • Physical barriers are the sole licensed adhesion prophylaxis adjuncts in the US and Europe.
  • Adhesion formation post-surgery remains a significant clinical challenge.
  • Novel biomaterials are needed for effective adhesion prevention.

Purpose of the Study:

  • To evaluate D,L-polylactide-epsilon-caprolactonetrimethylenecarbonate (PCT) copolymer as a biomaterial for adhesion prophylaxis.
  • To assess the biocompatibility and efficacy of PCT copolymer membranes in preventing post-surgical adhesions.

Main Methods:

  • PCT copolymer membranes synthesized via polymerization and processed using modified phase inversion and freeze-drying.
  • In vitro cytotoxicity assessed using fibroblast cultures.
  • In vivo efficacy evaluated in a rat surgical trauma model, with adhesion scoring and histological examination.
  • Human laparoscopic application tested in a myomectomy patient.

Main Results:

  • PCT copolymer demonstrated no in vitro cytotoxicity.
  • Significant reduction in adhesion quantity (32% vs. 78%) and quality in PCT-treated rats (P < .01).
  • No adverse reactions observed histologically in animal models; successful human laparoscopic application.

Conclusions:

  • PCT copolymer membrane is biocompatible within the abdominal cavity.
  • The material effectively decreases adhesions in an animal model.
  • PCT copolymer is suitable for human laparoscopic procedures, meriting further clinical investigation.