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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Published on: April 11, 2014

Ascorbigen: chemistry, occurrence, and biologic properties.

Anika E Wagner1, Gerald Rimbach

  • 1Institute of Human Nutrition and Food Science, Christian-Albrechts-University, D-24118 Kiel, Germany.

Clinics in Dermatology
|January 27, 2009
PubMed
Summary
This summary is machine-generated.

Ascorbigen (ABG), found in Brassica vegetables, is synthesized from glucobrassicin and L-ascorbic acid. ABG shows potential in cancer prevention and detoxification, with emerging use in cosmeceuticals.

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Area of Science:

  • Biochemistry
  • Nutritional Science
  • Cosmeceutical Science

Background:

  • Ascorbigen (ABG) is a glucosinolate derivative found in Brassica vegetables.
  • It is formed from glucobrassicin and L-ascorbic acid, with formation influenced by pH and temperature.
  • ABG is implicated in the anticarcinogenic properties of Brassica-rich diets and in xenobiotic detoxification.

Purpose of the Study:

  • To elucidate the formation and degradation pathways of Ascorbigen (ABG).
  • To explore the potential health benefits and applications of Ascorbigen (ABG).
  • To highlight the growing interest in Ascorbigen (ABG) for cosmeceutical applications.

Main Methods:

  • Investigated the enzymatic hydrolysis of glucobrassicin to indole-3-carbinol.
  • Examined the reaction of indole-3-carbinol with L-ascorbic acid to form ABG.
  • Analyzed ABG degradation products under varying pH conditions.

Main Results:

  • Ascorbigen (ABG) formation is dependent on pH and temperature.
  • Acidic degradation of ABG releases L-ascorbic acid and forms methylideneindolenine.
  • Alkaline degradation yields specific indolyl sugar derivatives.

Conclusions:

  • Ascorbigen (ABG) plays a role in the health benefits associated with Brassica vegetables.
  • ABG induces detoxification enzymes, suggesting a role in xenobiotic metabolism.
  • Further research is needed to establish the cellular mechanisms behind ABG's antiaging and UV-protective properties in cosmeceuticals.