Related Experiment Video

Updated: Jun 26, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Behavioral status of children with cryptogenic localization-related epilepsy

Saskia G M van Mil1, Rianne P Reijs, Mariette H J A van Hall

  • 1Epilepsy Centre Kempenhaeghe, Department of Research and Development, Maastricht University Hospital, Sterkselseweg 65, 5591 VE Heeze, The Netherlands. saskiavanmil@gmail.com

Journal of Child Neurology
|January 27, 2009
PubMed

Insights

Children with cryptogenic epilepsy show behavioral issues like internalizing behaviors and attention problems. These issues are similar to those seen in other epilepsy types, with more severe seizure types linked to externalizing behaviors.

Area of Science:

  • Pediatric Neurology
  • Child Psychiatry
  • Epileptology

Background:

  • Cryptogenic localization-related epilepsy (CLRE) is a significant neurological condition in children.
  • Behavioral and emotional problems are frequently observed in children with epilepsy.
  • Understanding the specific behavioral profile in CLRE is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the behavioral characteristics of children diagnosed with CLRE.
  • To identify specific behavioral patterns and their correlation with epilepsy-related factors.

Main Methods:

  • Utilized the Child Behavior Checklist (CBCL) for parent-reported behavioral assessments.
  • Evaluated 51 children diagnosed with CLRE.
  • Correlated behavioral subscale scores with epilepsy factors: seizure frequency, age at onset, epilepsy duration, number of antiepileptic drugs, and seizure type.

Main Results:

  • Children with CLRE exhibited clinical range scores on internalizing behavior, total behavior, and attentional problems subscales.
  • No significant relationship was found between seizure frequency, age at onset, epilepsy duration, or number of antiepileptic drugs and behavioral subscales.
  • A correlation was observed between seizure type severity and externalizing behaviors (delinquent, aggressive), although scores remained within the normal range.

Conclusions:

  • The behavioral problems identified in children with CLRE are comparable to those reported in other forms of childhood epilepsy.
  • Internalizing and attentional problems appear to be common features in this cohort.
  • While externalizing behaviors were linked to seizure severity, the overall behavioral profile does not significantly differ from other epilepsy types, suggesting a common underlying vulnerability.

More Related Videos

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe06:04

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Related Concept Videos

Epilepsy ll: Types01:22

Epilepsy ll: Types

Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...