Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic-Assisted Cytoreductive Surgery for Recurrent Endometrial Carcinoma with Iliac Vessel Involvement: A Multidisciplinary Approach.

Annals of surgical oncology·2026
Same author

ASO Author Reflections: Robotic Cytoreduction at the Vascular Interface: Redefining Surgical Limits.

Annals of surgical oncology·2026
Same author

Secondary Cytoreduction for Isolated Infra-renal Para-aortic Recurrence of High-Grade Serous Ovarian Carcinoma: A Robotic Approach.

Journal of minimally invasive gynecology·2026
Same author

Aortic aneurysms and dissections: Unmet needs from physicians and engineers perspectives.

Journal of biomechanics·2021
Same author

Pre- and Post-Transcatheter Aortic Valve Replacement Serum Brain Natriuretic Peptide Levels and All-Cause Mortality.

Cardiology·2020
Same author

Similar Procedural Success of Transcutaneous Aortic Valve Replacement with Prosthesis Valve Sizing by Either Three-Dimensional Transesophageal Echocardiography Modeling or Computed Tomography.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2020

Related Experiment Video

Updated: Jun 26, 2026

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

Modified alternating current defibrillation: a new defibrillation technique.

Shimon Rosenheck1, Shraga Gorni, Ioni Katz

  • 1Heart Institute, Hadassah Hebrew University Medical Center, Jerusalem, Israel. shimonr@ekmd.huji.ac.il

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|January 27, 2009
PubMed
Summary

A new modulated alternating current (AC) defibrillator is as effective as standard direct current (DC) devices. This safe and inexpensive home defibrillator may improve survival rates for ventricular fibrillation (VF).

More Related Videos

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Related Experiment Videos

Last Updated: Jun 26, 2026

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
09:47

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique

Published on: April 26, 2015

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
08:43

Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts

Published on: August 26, 2021

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Medical Devices

Background:

  • Defibrillation is the primary treatment for ventricular fibrillation (VF), with early intervention crucial for survival and recovery.
  • Current defibrillators, often direct current (DC) based, can be improved by readily available home units.
  • Alternating current (AC) defibrillation offers a potential alternative for accessible, effective treatment.

Purpose of the Study:

  • To develop a novel modulated AC defibrillator system.
  • To compare the efficacy and safety of the developed AC defibrillator against a standard DC defibrillator.
  • To assess the feasibility of a home-based defibrillator using AC technology.

Main Methods:

  • A computer-controlled, modulated AC defibrillation system was engineered using a high-voltage switch and transformer.
  • Efficacy and safety were evaluated in a porcine model (n=5) under general anesthesia.
  • Defibrillation threshold (DFT) was determined for both AC and DC shocks using a step-down protocol.

Main Results:

  • The modulated AC defibrillator demonstrated comparable efficacy to standard DC defibrillation.
  • The mean DFT for AC was 70.83 ± 24.81 J, versus 65.83 ± 12.41 J for DC (P=0.49).
  • No significant macroscopic tissue damage was observed with either AC or DC defibrillation.

Conclusions:

  • Modulated AC defibrillation is a safe and effective alternative to commercial DC defibrillation.
  • The developed AC defibrillator is cost-effective, requires minimal maintenance, and offers rapid, repeated shocks and pacing capabilities.
  • This technology presents an ideal platform for future automatic home defibrillators, potentially enhancing patient outcomes.