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Updated: Jun 26, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11
Chang-Ji Zheng1, Hyung-Eun Yu, Eun-Hee Kim
1Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Abstract:
A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillin-resistant S. aureus and quinolone-resistant S. aureus with MIC (microg/ml) of 0.5, which is similar with that of vancomycin, but 8-64 times higher activity than that of tetracycline.
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