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Related Experiment Videos

Finasteride-induced myalgia and HyperCKemia.

Talal M Al-Harbi1, Jennifer Kagan, Mark A Tarnopolsky

  • 1Neurology Division, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Journal of Clinical Neuromuscular Disease
|January 27, 2009
PubMed
Summary
This summary is machine-generated.

Finasteride, used for hair loss and prostate issues, can cause reversible muscle pain and elevated creatine kinase levels. Discontinuation of the drug led to symptom resolution in a reported case.

Related Experiment Videos

Area of Science:

  • Pharmacology
  • Biochemistry
  • Endocrinology

Background:

  • Finasteride is an antiandrogen medication inhibiting type II 5-alpha reductase, an enzyme converting testosterone to dihydrotestosterone.
  • It is prescribed for benign prostatic hyperplasia and male pattern baldness.
  • Potential side effects include sexual dysfunction and, rarely, myopathy.

Observation:

  • A 30-year-old man on finasteride for 10 years presented with diffuse muscle aches.
  • His creatine kinase (CK) levels were significantly elevated at 10,117 IU/L.
  • No muscle weakness or pigmenturia was noted.

Findings:

  • Symptoms resolved, and CK levels normalized to 256 IU/L within 3 weeks of discontinuing finasteride.
  • This case highlights a potential adverse reaction to finasteride therapy.
  • Reversible myalgia and hyperCKemia are associated with finasteride use.

Implications:

  • Clinicians should consider finasteride-induced myopathy in patients presenting with unexplained muscle pain and elevated CK levels.
  • Awareness of this potential side effect is crucial for patient safety and effective treatment management.
  • Further research may be warranted to elucidate the mechanism of finasteride-associated myopathy.