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Updated: Jun 26, 2026
Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
"Flash" solvent-free synthesis of triazoles using a supported catalyst
Ibtissem Jlalia1, Faouzi Meganem, Jean Herscovici
1Laboratoire de Pharmacologie Chimique et Génétique UMR8151 CNRS, U640 INSERM, IFR2769, Ecole Nationale Supérieure de Chimie de Paris, Paris, France. ibtissemj@yahoo.fr
Abstract:
A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst) A21*CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.
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