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Updated: Jun 26, 2026

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages
Published on: February 22, 2017
[Legionella pneumonia in patients treated with infliximab]
Hanne Vinter1, Henrik Ib Nielsen
1Infektionsmedicinsk Afdeling, Aalborg Sygehus Syd, DK-9000 Aalborg.
Abstract:
Therapy with tumour necrosis factor-alfa inhibitors is widely used in various inflammatory disorders, but adverse events from severe infections with intracellular pathogens may occur. We describe two cases of severe pulmonary legionellosis in patients treated with infliximab for Crohn's disease and psoriasis, respectively. We conclude that legionella infections are probably more frequent in patients receiving immunosuppressive therapy with tumour necrosis factor-alfa inhibitors than in the background population.
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