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Multiple conformational switches in a GTPase complex control co-translational protein targeting

Xin Zhang1, Christiane Schaffitzel, Nenad Ban

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

Proceedings of the National Academy of Sciences of the United States of America
|January 29, 2009
PubMed
Summary

The signal recognition particle (SRP) and SRP receptor (SR) GTPases control protein targeting via conformational changes, not a typical GTPase switch. Cargo accelerates assembly and delays activation, ensuring precise protein delivery.

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