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Intravitreal bevacizumab for neovascular glaucoma
Biljana Andrijević-Derk1, Zoran Vatavuk, Goran Bencić
1University Department of Ophthalmology, Sestre milosrdnice University Hospital, Zagreb, Croatia. biljana.andrijevic@zg.t-com.hr
Acta Clinica Croatica
|January 30, 2009
Summary
Intravitreal bevacizumab effectively reduced iris neovascularization and controlled intraocular pressure in neovascular glaucoma patients. This treatment shows promise as an adjunct therapy, though further long-term studies are needed.
Area of Science:
- Ophthalmology
- Vascular Biology
Background:
- Neovascular glaucoma (NVG) is characterized by abnormal blood vessel growth in the iris.
- Elevated intraocular pressure (IOP) in NVG can lead to vision loss.
Purpose of the Study:
- To evaluate the short-term effectiveness of intravitreal bevacizumab in managing neovascular glaucoma.
- To assess the impact of bevacizumab on iris neovascularization and intraocular pressure control.
Main Methods:
- Eleven NVG patients received a single intravitreal injection of 1.25 mg/0.1 mL bevacizumab.
- Three patients received bevacizumab preoperatively before pars plana vitrectomy.
- Follow-up duration was a minimum of 8 weeks, with additional therapy only if IOP was uncontrolled.
Main Results:
- Marked regression of iris neovascularization was observed within three postoperative days in all patients.
- Successful IOP control was achieved in seven patients.
- Four patients required additional therapy for IOP management.
- No adverse events related to intravitreal bevacizumab were reported.
Conclusions:
- Intravitreal bevacizumab demonstrates significant short-term efficacy in reducing iris neovascularization.
- It serves as a valuable adjunct therapy for neovascular glaucoma management.
- Further research is recommended to ascertain the long-term safety and efficacy of bevacizumab in NVG.
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