[Observation on morphology and function of macular in pathologic myopia]

Area of Science:

• Ophthalmology
• Medical Imaging
• Neuroscience

Context:

• Pathologic myopia is characterized by excessive elongation of the eyeball.
• Macular abnormalities are common in pathologic myopia, impacting visual function.
• Early detection and monitoring of macular changes are crucial for managing vision loss.

Purpose:

• To investigate macular morphology and function in pathologic myopia using fundus examination, OCT, and multifocal electroretinogram (mERG).
• To analyze the correlation between macular function, ocular axis length, refractive error, and corrected visual acuity in patients with pathologic myopia.

Summary:

• This study examined 36 eyes of 31 patients with pathologic myopia, divided into groups based on ocular axis length (> or = 30.00 mm vs. <30.00 mm).
• Results indicated significant differences in retinal neuroepithelial layer thickness and mERG P1 wave amplitude densities between the groups.
• Ocular axis length and myopia diopter showed negative correlations with corrected visual acuity and macular function (mERG P1 wave amplitude densities).

Impact:

• Findings highlight the association between increased ocular axis length, higher myopia, and impaired macular function, leading to visual acuity reduction.
• The combination of fundus examination, OCT, and mERG is valuable for early detection and monitoring of macular abnormalities in pathologic myopia.
• This research contributes to understanding the progression of vision loss in pathologic myopia and informs clinical management strategies.