Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrastructural changes in aging rat tracheal gland.

S Kasuga1

  • 1Central Research Laboratory, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.

Hiroshima Journal of Medical Sciences
|June 1, 1991
PubMed
Summary

Aging alters tracheal gland serous cells in rats, affecting mucus production and Golgi apparatus function. These changes may impair airway defense mechanisms, increasing susceptibility to respiratory diseases in older individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Active transport of glucose across the jejunal epithelium decreases with age in broiler chickens.

Poultry science·2019
Same author

Anti-allergic effects of aged garlic extract.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
Same author

Immunomodulation and antitumor activities of Aged Garlic Extract.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
Same author

Temporal trends of organochlorine pesticides in prawn (Macrobrachium nipponense) from Lake Kasumigaura, Japan, during 1978-2000.

Archives of environmental contamination and toxicology·2004
Same author

Estimation of the density of nymphs of the bush tick, Haemaphysalis longicornis (Acari: Ixodidae), by the catch effort method.

Experimental & applied acarology·2004
Same author

Prevention of psychological stress-induced immune suppression by aged garlic extract.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2002

Area of Science:

  • Cell Biology
  • Aging Research
  • Respiratory Physiology

Background:

  • Tracheal glands play a crucial role in airway defense.
  • Aging is associated with increased susceptibility to respiratory diseases.
  • Ultrastructural changes in aging tissues are not fully understood.

Purpose of the Study:

  • To investigate ultrastructural differences in tracheal glands between young and aged rats.
  • To examine the impact of aging on serous cell morphology and function.
  • To correlate observed changes with potential alterations in airway defense mechanisms.

Main Methods:

  • Comparative ultrastructural analysis using electron microscopy.
  • Examination of serous cells from young (8-17 weeks) and aged (20-30 months) rats.
  • Assessment of secretory granule morphology and Golgi apparatus development.

Main Results:

  • Aged rats exhibited bizonal secretory granules with abundant mucus, unlike the homogeneous granules in young rats.
  • The trans Golgi network was more developed and mesh-like in aged rat serous cells.
  • Alterations in Golgi apparatus function, including secretory granule formation and glycosylation, were observed in aged subjects.

Conclusions:

  • Aging significantly impacts tracheal gland serous cell ultrastructure and function.
  • Changes in the Golgi apparatus may lead to altered mucus properties and impaired airway defense.
  • These age-related modifications could contribute to the increased incidence of airway diseases in aging populations.

Related Experiment Videos