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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Two cases of dyshidrosiform pemphigoid with different presentations
1Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. myasuda@showa.gunma-u.ac.jp
Clinical and Experimental Dermatology
|January 30, 2009
Summary
Two cases of dyshidrosiform pemphigoid (DP) highlight its varied presentations. One case evolved into vesicular pemphigoid (VP) with novel antigen detection, while another mimicked bullous pemphigoid (BP).
Area of Science:
- Dermatology
- Immunodermatology
Background:
- Dyshidrosiform pemphigoid (DP) is a rare blistering skin disease.
- Understanding its variants and associations with other pemphigoid forms is crucial for diagnosis and management.
Observation:
- Case 1: A 65-year-old man initially diagnosed with dyshidrosis showed progression to widespread vesicles after treatment cessation, diagnosed as vesicular pemphigoid (VP) concomitant with or transformed from DP.
- Case 2: A 94-year-old woman presented with palmoplantar bullae that evolved into generalized oedematous erythema, characteristic of bullous pemphigoid (BP).
Findings:
- Western blotting revealed serum reactivity to 60 and 180 kDa antigens in Case 1, with the 60 kDa antigen being a novel finding in VP.
- The clinical evolution in both cases suggests a spectrum of disease within pemphigoid variants.
Implications:
- These cases expand the understanding of DP's clinical spectrum and its relationship with VP and BP.
- Further investigation into bullous pemphigoid antigen distribution may clarify mechanisms in localized pemphigoid forms like DP.
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