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Related Concept Videos

What are Lipids?01:38

What are Lipids?

Overview
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Assembly of the Lipid Bilayer in the ER01:28

Assembly of the Lipid Bilayer in the ER

Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...

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Related Experiment Video

Updated: Jun 26, 2026

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
11:30

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Liposomes in dermatology today.

J de Leeuw1, H C de Vijlder, P Bjerring

  • 1ZBC MultiCare, Outpatient Clinic for Dermatology and Laser Treatment, Hilversum, the Netherlands. deleeuw@erasmusmc.nl

Journal of the European Academy of Dermatology and Venereology : JEADV
|January 30, 2009
PubMed
Summary

Liposomes enhance topical drug delivery in dermatology by stabilizing medications and improving skin penetration. Encapsulating agents like 5-aminolevulinic acid (5-ALA) optimizes treatments such as Photodynamic Therapy (PDT).

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11:30

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Published on: August 31, 2019

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08:18

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09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

Area of Science:

  • Dermatology
  • Nanotechnology
  • Pharmaceutics

Background:

  • Liposomes are phospholipid vesicles with tunable properties for drug delivery.
  • Their amphipathic nature allows encapsulation of both hydrophilic and lipophilic drugs.
  • Liposome research has advanced significantly over 30 years.

Purpose of the Study:

  • To explore the therapeutic value of liposomes in topical dermatological applications.
  • To highlight liposomes' role as drug carriers, penetration enhancers, and stabilizers.
  • To discuss liposomes' potential in targeting pilosebaceous structures and improving treatments like Photodynamic Therapy (PDT).

Main Methods:

  • Review of liposome characteristics and applications in dermatology.
  • Analysis of liposomes' interaction with skin and drug delivery mechanisms.
  • Examination of clinical data on liposome-encapsulated 5-aminolevulinic acid (5-ALA).

Main Results:

  • Liposomes improve drug stabilization, skin penetration, and reduce irritation.
  • They offer sustained drug release and epidermal hydration.
  • Liposomes can target pilosebaceous units, benefiting hair follicle-associated disorders.
  • Clinical data show improved Fluorescence Diagnosis (FD) and PDT outcomes with 5-ALA liposomes.

Conclusions:

  • Liposomes are versatile carriers with significant therapeutic potential in dermatology.
  • Their ability to enhance drug delivery and target specific structures makes them valuable for various skin conditions.
  • Liposome-encapsulated 5-ALA demonstrates improved efficacy in PDT and FD.