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Updated: Jun 26, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
Published on: January 9, 2026
[Multi-facetted clinical presentation of thrombotic thrombocytopenic purpura]
Carsten Utoft Niemann1, Jesper Jurlander, Gedske Daugaard
1Medicinsk Haematologisk Afdeling L, Rigshospitalet, DK-2100 København Ø. niemann@dadlnet.dk.
Abstract:
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathic disease. TTP is due to reduced activity of the von Willebrand factor which cleaves ADAMTS13. The disease is characterized by thrombocytopenia (<20 billion/l) intravascular Coombs-negative haemolysis and schistocytes in blood smears. Determination of the ADAMTS13-activity is now becoming available as a routine analysis. We present two cases that illustrate the multi-facetted clinical presentation under which TTP occurs. The importance of access to ADAMTS13 measurements is stressed.
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