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Updated: Jun 26, 2026
11:14
Modeling Paracrine Noncanonical Wnt Signaling In Vitro
Published on: December 10, 2021
Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis
Yingjie Liu1, Nibedita Chattopadhyay, Shan Qin
1Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Development (Cambridge, England)
|January 30, 2009
Summary
Integrin and growth factor receptors coordinate to control Wnt7b gene expression in developing mouse kidneys. This signaling pathway regulates epithelial cell survival, crucial for kidney papilla formation and maturation.
Area of Science:
- Developmental Biology
- Cell Signaling
- Molecular Biology
Background:
- Integrin and receptor tyrosine kinase pathways transmit environmental cues into cells.
- Wnt proteins are key regulators of morphogenetic events.
- Regulation of Wnt gene expression remains poorly understood.
Purpose of the Study:
- To investigate the coordinated signaling between integrins and growth factor receptors.
- To elucidate the regulation of Wnt gene expression during kidney development.
- To understand the role of Wnt signaling in epithelial morphogenesis.
Main Methods:
- Utilized mouse models to study gene expression.
- Investigated signaling pathways involving alpha3beta1 integrin and c-Met.
- Analyzed the effects of Wnt signaling on epithelial cell survival and tubule elongation.
Main Results:
- Demonstrated coordinate signaling between alpha3beta1 integrin and c-Met.
- Showed that this coordinated signaling regulates Wnt7b expression in the mouse kidney.
- Identified Wnt signaling's role in regulating epithelial cell survival in the developing kidney papilla.
Conclusions:
- Integrin and growth factor receptor signals integrate to regulate Wnt gene expression.
- This integrated signaling pathway is essential for kidney morphogenesis.
- The study provides insights into how extracellular signals control developmental processes.
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