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Initial growth deceleration during GnRH analogue therapy for precocious puberty
Frances Mouat1, Paul L Hofman, Craig Jefferies
1The Liggins Institute, University of Auckland, Auckland, New Zealand.
Clinical Endocrinology
|January 31, 2009
Summary
Goserelin showed greater initial growth suppression than leuprolide in children with precocious puberty. Relative tall stature influenced treatment response, with both gonadotropin-releasing hormone (GnRH) analogues effectively suppressing puberty biochemically.
Area of Science:
- Pediatric Endocrinology
- Reproductive Medicine
Background:
- Precocious puberty requires treatment to prevent adverse outcomes.
- Gonadotropin-releasing hormone (GnRH) analogues are standard treatment.
- Goserelin and leuprolide are commonly used GnRH analogues with varying efficacy.
Purpose of the Study:
- To compare goserelin and leuprolide efficacy in decelerating growth and weight gain.
- To assess the impact of initial treatment response over 12 months.
- To identify factors influencing treatment effectiveness in precocious puberty.
Main Methods:
- Retrospective cohort analysis of 40 children with precocious puberty.
- Comparison of goserelin versus leuprolide treatment groups.
- Primary outcomes: change in height SDS and BMI SDS over 12 months.
Main Results:
- Both GnRH analogues achieved similar luteinizing hormone (LH) suppression.
- Goserelin demonstrated significantly greater growth suppression in the first 6 months (P=0.025).
- Relative tall stature, advanced bone age, and BMI SDS predicted initial growth response.
Conclusions:
- Goserelin and leuprolide effectively suppress puberty biochemically.
- Goserelin offers superior initial linear growth deceleration in the first 6 months.
- Relative tall stature is a key factor in predicting treatment response.
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