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Updated: Jun 26, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Intertriginous pustular psoriasis
Jane S Bellet1, Sarah L Chamlin, Albert C Yan
1Departments of Dermatology and Pediatrics at Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Insights
Infantile pustular psoriasis, often misdiagnosed, presents as neck rashes. This condition may indicate widespread psoriasis development later in life.
Area of Science:
- Dermatology
- Pediatrics
Background:
- Infantile pustular psoriasis is a rare condition.
- It often presents as erythematous papules or pustules on the neck and intertriginous areas.
Observation:
- Six infant cases are described, with initial misdiagnoses including dermatitis or infections.
- Biopsy confirmed pustular psoriasis in five of six infants.
Findings:
- Psoriasis became widespread in four cases over time.
- Treatment involved topical and systemic therapies, with some cases being recalcitrant.
Implications:
- Pustular psoriasis should be considered in infants with intertriginous papulopustular eruptions.
- Infantile-onset intertriginous pustular psoriasis may predict future widespread disease.
Abstract:
We describe 6 patients who presented during infancy with erythematous papules or pustules localized to the neck and sometimes other intertriginous areas as well. Most of these infants were initially thought to have dermatitis or a bacterial or candidal infection. A biopsy specimen established the diagnosis of pustular psoriasis in 5 of the 6 cases. In 4 cases, the psoriasis became more widespread during the months to years after diagnosis. Treatment included topical therapy in all cases and systemic therapy in 3 cases. Two cases have remained particularly recalcitrant. Pustular psoriasis must be considered in the differential diagnosis of an intertriginous papulopustular eruption in an infant. Pustular psoriasis presenting in the intertriginous areas, and particularly the neck, seems specific to infants and may portend progressive extension to widespread involvement. A limitation is that this was a retrospective case series.
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