Deployment performance and retrievability of the Cook Celect vena cava filter

Area of Science:

• Vascular Surgery
• Medical Device Engineering
• Animal Models in Research

Background:

• Inferior vena cava filters are crucial for preventing pulmonary embolism.
• Retrievable filters offer a temporary solution, reducing long-term complications.
• Assessing the long-term safety and efficacy of retrievable filters is essential.

Purpose of the Study:

• To evaluate the safety, performance, and retrievability of the Cook Celect vena cava filter.
• To determine the feasibility of filter retrieval at various time points up to 393 days.
• To assess the histological impact of the filter on the vena cava.

Main Methods:

• The Cook Celect vena cava filter was implanted in series in 20 sheep.
• Filter retrieval was attempted at 30, 60, 90, 180, and 360 days post-implantation.
• Vena cava segments were analyzed for healing and injury after retrieval or euthanasia.

Main Results:

• All 30 filter retrieval attempts were successful.
• No filter migration or deformation was observed.
• Mild intimal hyperplasia was noted, with no evidence of vena cava injury.

Conclusions:

• The Cook Celect vena cava filter is safe and retrievable for up to 393 days in an ovine model.
• The filter demonstrated good performance and minimal adverse effects on the vena cava.
• This study supports the use of the Celect filter as a temporary inferior vena cava filter.