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26:48
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Measles with acute disseminated encephalomyelitis (ADEM)
J Chowdhary1, S M Ashraf, K Khajuria
1Department of Pediatrics, G.B. Pant Hospital, Govt. Medical College, Cant Sonwar, Srinagar, India.
Indian Pediatrics
|January 31, 2009
Summary
A vaccinated seven-year-old developed measles-associated acute disseminated encephalomyelitis (ADEM). Prompt treatment with corticosteroids led to a full recovery, highlighting ADEM
Area of Science:
- Neurology
- Immunology
- Pediatrics
Background:
- Acute disseminated encephalomyelitis (ADEM) is a rare, immune-mediated demyelinating disease.
- Measles infection is a known, albeit infrequent, trigger for ADEM.
- Vaccination is highly effective in preventing measles, but breakthrough infections can occur.
Observation:
- A seven-year-old male presented with symptoms suggestive of ADEM.
- The patient had received routine measles vaccination in infancy.
- Diagnostic workup included serum measles antibodies and brain MRI.
Findings:
- The patient was diagnosed with measles-associated acute disseminated encephalomyelitis (ADEM).
- Despite prior measles vaccination, the patient developed ADEM post-infection.
- High-dose corticosteroid therapy and supportive care resulted in complete neurological and physical recovery.
Implications:
- This case underscores that ADEM can occur even after measles vaccination.
- Early diagnosis and aggressive treatment with corticosteroids are crucial for favorable outcomes in ADEM.
- Continued vigilance for vaccine-preventable diseases and their complications is warranted.
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