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Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
06:08

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Published on: February 7, 2014

Aortic pulse wave velocity predicts cardiovascular mortality in middle-aged and elderly Japanese men

Noriko Inoue1, Ryo Maeda, Hideshi Kawakami

  • 1Hiroshima City Medical Association Clinical Laboratory Center, 3-8-6 Senda-machi, Naka-ku, Hiroshima 730-8611, Japan. ninoue@gentaikyo.or.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|January 31, 2009
PubMed

Insights

Increased aortic pulse wave velocity (PWV) predicts higher cardiovascular mortality risk in middle-aged and elderly Japanese men. This study highlights PWV as a crucial indicator for cardiovascular health in this demographic.

Area of Science:

  • Cardiovascular research
  • Gerontology
  • Public health

Background:

  • Aortic pulse wave velocity (PWV) is a noninvasive measure of arterial stiffness.
  • Arterial stiffness is a significant risk factor for cardiovascular events.

Purpose of the Study:

  • To investigate the association between PWV and cardiovascular mortality.
  • To examine this relationship in a cohort of middle-aged and elderly Japanese men.

Main Methods:

  • Longitudinal study design.
  • Recruited 3,960 men aged 50-69 years (1988-2003).
  • Measured PWV, standardized for diastolic blood pressure, and followed participants for an average of 8.2 years.

Main Results:

  • Mortality from all causes and cardiovascular disease significantly increased with higher PWV.
  • The highest quartile of PWV (>9.0 m/s) showed a 1.83-fold increased risk of cardiovascular mortality compared to the lowest quartile (<7.5 m/s).

Conclusions:

  • Elevated aortic pulse wave velocity is a significant predictor of cardiovascular mortality.
  • PWV measurement can aid in risk stratification for cardiovascular disease in older Japanese men.
Abstract

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