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Related Concept Videos

Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants


Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...

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Related Experiment Video

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An Operant Intra-/Extra-dimensional Set-shift Task for Mice
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Published on: January 22, 2016

Nicotine does not enhance discrimination performance in a temporal bisection procedure.

Ryan D Ward1, Scott T Barrett, Robert N Johnson

  • 1Department of Psychology, Utah State University, Utah, USA. rw2353@columbia.edu

Behavioural Pharmacology
|January 31, 2009
PubMed
Summary

Nicotine disrupted temporal discrimination in pigeons by impairing stimulus control, not timing. Mecamylamine did not block this effect, suggesting it

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Last Updated: Jun 26, 2026

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Area of Science:

  • Behavioral neuroscience
  • Psychopharmacology

Background:

  • Drug administration can disrupt temporal discrimination tasks.
  • Nicotine is known to enhance attention.

Purpose of the Study:

  • To assess nicotine's effects on temporal discrimination in pigeons.
  • To differentiate effects on stimulus control versus timing.

Main Methods:

  • Pigeons were trained on a temporal discrimination task with varying sample durations.
  • Nicotine's effects were analyzed using a model separating stimulus control, bias, and sensitivity.
  • Mecamylamine was used to test for antagonism of nicotine's effects.

Main Results:

  • Nicotine selectively decreased stimulus control.
  • Nicotine did not significantly alter timing measures.
  • Mecamylamine failed to antagonize nicotine's disruptive effects.

Conclusions:

  • Nicotine disrupts temporal discrimination by affecting stimulus control, not timing.
  • The observed effects may not be specific to nicotine's pharmacology.
  • Quantitative analysis is crucial for understanding drug effects on behavior.