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The molecular programme of tumour reversion: the steps beyond malignant transformation

Adam Telerman1, Robert Amson

  • 1LBPA, UMR 8113, Ecole Normale Supérieure, 61 Avenue du Président Wilson, 94235 Cachan, France. adam.telerman@lbpa.ens-cachan.fr

Nature Reviews. Cancer
|January 31, 2009
PubMed

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Such genes that act...