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Related Concept Videos

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...

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Related Experiment Video

Updated: Jun 26, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Inside FlyBase: biocuration as a career.

Susan St Pierre1, Peter McQuilton

  • 1Harvard University, Molecular and Cellular Biology, Cambridge, Massachusetts, USA.

Fly
|February 3, 2009
PubMed
Summary
This summary is machine-generated.

Biocurators are essential for managing rapidly advancing biological data. This article details the biocuration process from the perspective of FlyBase curators, emphasizing data standardization and accessibility for researchers.

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Last Updated: Jun 26, 2026

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Area of Science:

  • Biological Sciences
  • Bioinformatics
  • Data Management

Background:

  • Biological research generates vast amounts of data.
  • Effective data management is crucial for scientific progress.
  • Standardization and accessibility are key challenges in biological data handling.

Purpose of the Study:

  • To describe the role and process of biocuration.
  • To provide insights from the perspective of experienced FlyBase curators.
  • To highlight the importance of data standardization and accessibility.

Main Methods:

  • Describing the practical workflow of biocuration.
  • Illustrating the tasks involved in capturing, standardizing, and organizing biological data.
  • Sharing the experiences and methodologies of FlyBase curators.

Main Results:

  • Biocuration involves systematic data handling.
  • Standardized data enhances research reproducibility and collaboration.
  • Accessible data repositories accelerate scientific discovery.

Conclusions:

  • Biocurators play a vital role in the biological sciences.
  • Effective biocuration practices are fundamental for managing and leveraging research data.
  • The FlyBase curation experience offers a model for data management in other biological domains.