Related Experiment Video
Updated: Jun 26, 2026
08:38
Targeted DNA Methylation Analysis by Next-generation Sequencing
Published on: February 24, 2015
DNA methylation signature analysis: how easy is it to perform?
Christina Piperi1, Elena Farmaki, Fotis Vlastos
1Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece.
Journal of Biomolecular Techniques : JBT
|February 3, 2009
Abstract:
Epigenetic changes, or heritable alterations in gene function that do not affect DNA sequence, are rapidly gaining acceptance as co-conspirators in carcinogenesis. Although DNA methylation signature analysis by methylation-specific polymerase chain reaction has been a breakthrough method in speed and sensitivity for gene methylation studies, several factors still limit its application as a routine diagnostic and prognostic test.
