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Updated: Jun 25, 2026
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Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR
Published on: July 30, 2011
De Novo identification of single nucleotide mutations in Caenorhabditis elegans using array comparative genomic
Jason S Maydan1, H Mark Okada, Stephane Flibotte
1Department of Zoology, University of British Columbia V6T 1Z4, Vancouver, British Columbia, Canada.
Genetics
|February 5, 2009
Abstract:
Array comparative genomic hybridization (aCGH) has been used primarily to detect copy-number variants between two genomes. Here we report using aCGH to detect single nucleotide mutations on oligonucleotide microarrays with overlapping 50-mer probes. This technique represents a powerful method for rapidly detecting novel homozygous single nucleotide mutations in any organism with a sequenced reference genome.
