Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systemic inflammatory response following hip fracture in older people: postoperative CRP and PCT dynamics and their association with coagulation and renal function.

GeroScience·2026
Same author

Prehospital pain management in older adults with proximal Femur fractures: current practices and implications for delirium prevention.

SAGE open medicine·2026
Same author

Reduced perioperative sensory impairment could lower postoperative delirium incidence: a before-and-after study in older patients with hip fracture.

BMC geriatrics·2025
Same author

Development of a laboratory-based frailty index for risk prediction in elderly trauma patients with hip fractures.

GeroScience·2025
Same author

Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment.

GeroScience·2022
Same author

Differences in hip fracture care in Europe: a systematic review of recent annual reports of hip fracture registries.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2021
Same journal

[Journal Club].

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Effect of anticholinergic burden on cardiac functions in older patients.

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

[Communication in later life under institutional conditions : Professional perspectives on communication of ageing people with profound intellectual and multiple disabilities].

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
Same journal

Zeitschrift fur Gerontologie und Geriatrie·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

[Delirium in the elderly].

Manfred Gogol1

  • 1Klinik für Geriatrie, Krankenhaus Lindenbrunn, Lindenbrunn 1, 31863, Coppenbrügge, Germany. gogol@krankenhaus-lindenbrunn.de

Zeitschrift Fur Gerontologie Und Geriatrie
|February 5, 2009
PubMed
Summary
This summary is machine-generated.

Delirium is a serious condition in elderly patients, often multifactorial and linked to neurotransmitter changes. Early diagnosis and treatment are crucial to reduce mortality, hospital stays, and healthcare costs.

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

Related Experiment Videos

Last Updated: Jun 25, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

Area of Science:

  • Geriatrics
  • Neuroscience
  • Internal Medicine

Context:

  • Delirium is a prevalent and critical condition affecting elderly inpatients, frequently necessitating hospital admission.
  • Its occurrence can be primary or secondary to other medical issues, with incidence rates varying significantly up to 90% across different healthcare settings.

Purpose:

  • To highlight the significant impact of delirium on patient outcomes and healthcare systems.
  • To emphasize the need for structured diagnostic and therapeutic approaches for delirium management.

Summary:

  • Delirium, a complex condition with multifactorial pathogenesis involving neurotransmitter alterations, poses a substantial risk to elderly patients.
  • It is associated with increased mortality, functional decline, cognitive impairment, prolonged hospitalizations, and elevated healthcare expenditures.

Impact:

  • Implementing delirium as a quality indicator in hospital medicine is recommended to improve patient care.
  • Further research is essential to fully elucidate delirium's pathogenesis and optimize management strategies.