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Updated: Sep 9, 2025
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
Published on: February 27, 2018
Reduced perioperative sensory impairment could lower postoperative delirium incidence: a before-and-after study in
Jan Wilhelm Busse1, Alexander Ranker2,3, Manfred Gogol4
1Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, Hannover, 30625, Germany. Busse.Jan@mh-hannover.de.
Background:
Postoperative delirium (POD) is a common complication in older patients. Multicomponent prevention reduces POD but requires substantial resources. The effect of single interventions derived from multicomponent programs remains elusive, but it is essential to assess their effect to identify which components are meaningful. This study investigates whether a single intervention from a multicomponent program may reduce the incidence of POD.
Methods:
This prospective, single-center before-and-after study evaluated older surgery patients at a university hospital's geriatric trauma center between July 2020 and November 2021. Inclusion criteria were age ≥ 70 years and a proximal femoral fracture. A control cohort (CC) left their dentures, vision, and hearing aids on the ward throughout surgery, while an intervention cohort (IC) used them until anesthesia induction and received them back when they regained consciousness. Therefore, IC obtained a transport case for hygienic storage and perioperative device management. The time of sensory aid removal was measured to ensure proper implementation. Outcomes were the incidence of POD (assessed via the 3-min Diagnostic Confusion Assessment Method at admission and twice daily for three days postoperatively), patient satisfaction, and recovery (evaluated via Quality of Recovery-9), length of hospital stay, postoperative monitoring time, Barthel-index, and 30-day mortality.
Results:
248 patients were screened for eligibility. Following a dropout rate of n = 166, the cohorts were: CC n = 40 and IC n = 42. Both cohorts had similar baseline and treatment characteristics. The intervention significantly reduced the median time of sensory aid removal (CC 12h 14min, IC 12min, p < 0.001), and the incidence of POD overall (CC 65.0%, IC 40.5%, p = 0.026). The length of hospital stay and long-term recovery outcomes remained insignificant. However, postoperative monitoring time correlated with time of sensory aid removal (rs = 0.518, p < 0.001, n = 62), and median quality of recovery improved on average (CC 12.75, IC 15.62, p < 0.001).
Conclusion:
Reduced perioperative sensory impairment may reduce the incidence of POD, decrease postoperative monitoring time, and be associated with a better postoperative recovery. Therefore, multimodal preventative efforts should include reducing sensory aid removal.
Trial Registration:
German Clinical Trial Register (DRKS-ID DRKS00022085); 07/07/2020.
